The Future of Particle Physics

After a very brief review of twentieth century elementary particle physics, prospects for the next century are discussed. First and most important are technological limits of opportunities; next, the future experimental program, and finally the status of the theory, in particular its limitations as well as its opportunities.Comment: Invited talk given at the International Conference on Fundamental Sciences: Mathematics and Theoretical Physics, Singapore, 13-17 March 200

Perception of Bullying Among Faculty Members: Implications for African American Males

This dissertation examines the various perceptions of bullying and the need for a theory that is culturally sensitive and provides the victims with a voice. Bullying adds additional stressors to the lives of its victim, due to lack of research on bullying and its impact on African American males in secondary education, this dissertation primary focus is this population. Implications for a unified definition of bullying, training that is applicable across the cultural spectrum, and the need for continued research are emphasized. The dissertation is composed of three phenomenological products that together examined the many diverse aspects of bullying. Using Critical Race Theory (CRT), this dissertation examined its applicability to bullying. Using qualitative, exploratory methods, this dissertation aimed to gain a better understanding of some of the perceptions held by middle school faculty members as it relates to bullying. The presentation shared the findings of the study with school faculty members at a national conference. The conceptual framework of this dissertation is CRT. The dissertation explored the premise of CRT and its effective application to bullying. The author suggests that (CRT) should be used as the theoretical foundation for understanding bullying and devising a workable plan to decrease incidents of bullying. CRT affords a holistically look at bullying through a lens that is culturally sensitive and allows the victims to have a voice. Identifying perceptions of bullying is vital to encouraging victims to come forth with the comfort of knowing they will be understood and something will be done. Understanding how faculty members perceive bullying may aid in creating trainings that will improve their understanding of bullying, especially with African American males. To accomplish this qualitative data was gathered through the use of one-on-one professional interviews to gain a baseline of school faculty member’s perception of bullying. The qualitative data gathered from the professional interviews were then shared with other middle school faculty members at the National Conference on Bullying in Reno, Nevada in the form of a PowerPoint presentation. The study revealed that there is a distinct difference in the way that more seasoned school faculty and younger faculty members define bullying. There also exists an interpretation difference of incidents of bullying and when male versus female middles school faculty do intervene in incidents of bullying. All respondents indicated that there is a dire need for training and a unified definition of bullying

Perception of Bullying Among Faculty Members: Implications for African American Males

This dissertation examines the various perceptions of bullying and the need for a theory that is culturally sensitive and provides the victims with a voice. Bullying adds additional stressors to the lives of its victim, due to lack of research on bullying and its impact on African American males in secondary education, this dissertation primary focus is this population. Implications for a unified definition of bullying, training that is applicable across the cultural spectrum, and the need for continued research are emphasized. The dissertation is composed of three phenomenological products that together examined the many diverse aspects of bullying. Using Critical Race Theory (CRT), this dissertation examined its applicability to bullying. Using qualitative, exploratory methods, this dissertation aimed to gain a better understanding of some of the perceptions held by middle school faculty members as it relates to bullying. The presentation shared the findings of the study with school faculty members at a national conference. The conceptual framework of this dissertation is CRT. The dissertation explored the premise of CRT and its effective application to bullying. The author suggests that (CRT) should be used as the theoretical foundation for understanding bullying and devising a workable plan to decrease incidents of bullying. CRT affords a holistically look at bullying through a lens that is culturally sensitive and allows the victims to have a voice. Identifying perceptions of bullying is vital to encouraging victims to come forth with the comfort of knowing they will be understood and something will be done. Understanding how faculty members perceive bullying may aid in creating trainings that will improve their understanding of bullying, especially with African American males. To accomplish this qualitative data was gathered through the use of one-on-one professional interviews to gain a baseline of school faculty member’s perception of bullying. The qualitative data gathered from the professional interviews were then shared with other middle school faculty members at the National Conference on Bullying in Reno, Nevada in the form of a PowerPoint presentation. The study revealed that there is a distinct difference in the way that more seasoned school faculty and younger faculty members define bullying. There also exists an interpretation difference of incidents of bullying and when male versus female middles school faculty do intervene in incidents of bullying. All respondents indicated that there is a dire need for training and a unified definition of bullying

Model-Independent Description and Large Hadron Collider Implications of Suppressed Two-Photon Decay of a Light Higgs Boson

For a Standard Model Higgs boson with mass between 115 GeV and 150 GeV, the two-photon decay mode is important for discovery at the Large Hadron Collider (LHC). We describe the interactions of a light Higgs boson in a more model-independent fashion, and consider the parameter space where there is no two-photon decay mode. We argue from generalities that analysis of the $t\bar t h$ discovery mode outside its normally thought of range of applicability is especially needed under these circumstances. We demonstrate the general conclusion with a specific example of parameters of a type I two-Higgs doublet theory, motivated by ideas in strongly coupled model building. We then specify a complete set of branching fractions and discuss the implications for the LHC.Comment: 4 pages, 4 figure

Multi-lectin Affinity Chromatography and Quantitative Proteomic Analysis Reveal Differential Glycoform Levels between Prostate Cancer and Benign Prostatic Hyperplasia Sera.

Currently prostate-specific antigen is used for prostate cancer (PCa) screening, however it lacks the necessary specificity for differentiating PCa from other diseases of the prostate such as benign prostatic hyperplasia (BPH), presenting a clinical need to distinguish these cases at the molecular level. Protein glycosylation plays an important role in a number of cellular processes involved in neoplastic progression and is aberrant in PCa. In this study, we systematically interrogate the alterations in the circulating levels of hundreds of serum proteins and their glycoforms in PCa and BPH samples using multi-lectin affinity chromatography and quantitative mass spectrometry-based proteomics. Specific lectins (AAL, PHA-L and PHA-E) were used to target and chromatographically separate core-fucosylated and highly-branched protein glycoforms for analysis, as differential expression of these glycan types have been previously associated with PCa. Global levels of CD5L, CFP, C8A, BST1, and C7 were significantly increased in the PCa samples. Notable glycoform-specific alterations between BPH and PCa were identified among proteins CD163, C4A, and ATRN in the PHA-L/E fraction and among C4BPB and AZGP1 glycoforms in the AAL fraction. Despite these modest differences, substantial similarities in glycoproteomic profiles were observed between PCa and BPH sera

A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers.

Novel biomarker assays and upgraded analytical tools are urgently needed to accurately discriminate benign prostatic hypertrophy (BPH) from prostate cancer (CaP). To address this unmet clinical need, we report a piezeoelectric/magnetic bead-based assay to quantitate prostate specific antigen (PSA; free and total), prostatic acid phosphatase, carbonic anhydrase 1 (CA1), osteonectin, IL-6 soluble receptor (IL-6sr), and spondin-2. We used the sensor to measure these seven proteins in serum samples from 120 benign prostate hypertrophy patients and 100 Gleason score 6 and 7 CaP using serum samples previously collected and banked. The results were analyzed with receiver operator characteristic curve analysis. There were significant differences between BPH and CaP patients in the PSA, CA1, and spondin-2 assays. The highest AUC discrimination was achieved with a spondin-2 OR free/total PSA operation--the area under the curve was 0.84 with a p value below 10(-6). Some of these data seem to contradict previous reports and highlight the importance of sample selection and proper assay building in the development of biomarker measurement schemes. This bead-based system offers important advantages in assay building including low cost, high throughput, and rapid identification of an optimal matched antibody pair